The Nexus web application does not support IE at the moment, as of 2021 R1.
In a local installation of Nexus, movies/animations/videos(mp4) are broken and will not play in Safari at the moment, as of 2021 R1. Remote deployments however do not have this problem.
Logging in and out of the Nexus web interface that is embedded inside the Nexus Template Editor is not supported. Please disconnect from the server using the Template Editor's 'File' menu and reconnect with the new credentials if you would like to switch users.
Nexus launched from a UNC location is not supported at the moment, as of 2021 R1.